| Dragon Warrior I & II (USA) | |
| Dragon Warrior III (USA) | |
| Dragon Warrior Monsters (USA) | |
| Dragon Warrior Monsters 2 - Cobi's Journey (USA) | |
| Dragon Warrior Monsters 2 - Tara's Adventure (USA) | |
| Dragon's Lair (USA) (En,Ja,Fr,De,Es,Zh) | |
| Driver - | |
| You are the Wheelman (USA) (En,Fr,De,Es,It) | |
| Dropzone (Europe) | |
| DT - Lords of Genomes (Japan) | |
| Duke Nukem (Europe) (En,Fr,De,Es,It) | |
| Duke Nukem (USA) (En,Fr,De,Es,It) | |
| Dukes of Hazzard, The - Racing for Home (Europe) (En,Fr,De) | |
| Dukes of Hazzard, The - Racing for Home (USA) | |
| Dungeon Savior (Japan) | |
| DX Jinsei Game (Japan) | |
| DX Monopoly GB (Japan) | |
| DynaMike (Europe) (Proto) | |
| E.T. and the Cosmic Garden (Europe) (En,Fr,De,Es,It,Nl) | |
| E.T. and the Cosmic Garden (USA) | |
| E.T. The Extra Terrestrial - Digital Companion (USA) | |
| E.T. The Extra Terrestrial - Escape from Planet Earth (Europe) (En,Fr,De,Es,It,Nl) | |
| E.T. The Extra Terrestrial - Escape from Planet Earth (USA) | |
| Earthworm Jim - Menace 2 the Galaxy (USA) | |
| ECW Hardcore Revolution (USA) | |
| Elevator Action EX (Europe) (En,Fr,De,Es,It) | |
| Elevator Action EX (Japan) | |
| Elie no Atelier GB (Japan) | |
| Elmo's 123s (USA) | |
| Elmo's ABCs (USA) | |
| Emperor's New Groove, The (Europe) (En,Fr,De,Es,It) | |
| Emperor's New Groove, The (USA) | |
| ESPN International Track & Field (USA) | |
| ESPN National Hockey Night (USA) | |
| Estpolis Denki - Yomigaeru Densetsu (Japan) | |
| European Super League (Europe) (En,Fr,De,Es,It) | |
| Evel Knievel (Europe) (En,Fr,De,Es,It,Nl,Sv) | |
| Evel Knievel (USA) | |
| Extreme Ghostbusters (Europe) (En,Fr,De,Es,It,Pt) | |
| Extreme Sports with the Berenstain Bears (USA) (En,Fr,De,Es,It) | |
| F-1 World Grand Prix (Europe) (En,Fr,De,Es) | |
| F-18 Thunder Strike (USA, Europe) | |
| F.A. Premier League Stars 2001, The (Europe) | |
| F1 Championship Season 2000 (Europe) (En,Fr,De,Es,It) | |
| F1 Racing Championship (Europe) (En,Fr,De,Es,It) | |
| F1 Racing Championship (Europe) (En,Fr,De,Es,It) (Beta) | |
| F1 World Grand Prix II for Game Boy Color (Europe) (En,Fr,De,Es) | |
| F1 World Grand Prix II for Game Boy Color (Japan) (En,Ja) | |
| F1 World Grand Prix II for Game Boy Color (USA) (En,Fr,De,Es) | |
| Fairy Kitty no Kaiun Jiten - Yousei no Kuni no Uranai Shugyou (Japan) | |
| Ferret Monogatari (Japan) | |