| Shining Force II - The Sword of Hajya (USA, Europe) | |
| Side Pocket (USA) | |
| Simpsons, The - Bart vs. The Space Mutants (USA, Europe) | |
| Simpsons, The - Bart vs. The World (USA, Europe) | |
| Skweek (Japan) | |
| Slider (USA, Europe) | |
| Smurfs, The (Europe) (En,Fr,De,Es) | |
| Solitaire Funpak (USA, Europe) | |
| Solitaire Poker (USA, Europe) | |
| Sonic & Tails (Japan) | |
| Sonic & Tails 2 (Japan) | |
| Sonic Blast (World) | |
| Sonic Chaos (USA, Europe) | |
| Sonic Drift (Japan) | |
| Sonic Drift (Japan) (Sample) | |
| Sonic Drift 2 (Japan) | |
| Sonic Labyrinth (USA, Europe) | |
| Sonic Spinball (USA, Europe) | |
| Sonic The Hedgehog - Triple Trouble (USA, Europe) | |
| Sonic The Hedgehog (Japan) | |
| Sonic The Hedgehog (World) (Proto) | |
| Sonic The Hedgehog (World) (v1.1) | |
| Sonic The Hedgehog 2 (World) | |
| Soukoban (Japan) | |
| Space Harrier (USA, Europe) | |
| Spider-Man - Return of the Sinister Six (USA, Europe) | |
| Spider-Man and the X-Men in Arcade's Revenge (USA, Europe) | |
| Spider-Man vs. The Kingpin (USA, Europe) | |
| Spirou (Europe) (Proto) | |
| Sports Illustrated Championship Football & Baseball (USA, Europe) | |
| Sports Trivia - Championship Edition (USA, Europe) | |
| Sports Trivia (USA, Europe) | |
| Star Trek - The Next Generation (USA, Europe) | |
| Star Trek Generations - Beyond the Nexus (USA, Europe) | |
| Star Wars (Europe) | |
| Star Wars (USA) | |
| Stargate (USA, Europe) | |
| Streets of Rage (World) | |
| Streets of Rage II (World) | |
| Super Battletank (USA) | |
| Super Columns (Japan) | |
| Super Columns (USA) | |
| Super Golf (Japan) | |
| Super Kick Off (Japan) | |
| Super Momotarou Dentetsu III (Japan) | |
| Super Monaco GP (Japan) | |
| Super Monaco GP (USA, Europe) | |
| Super Off Road (USA, Europe) | |
| Super Return of the Jedi (USA, Europe) | |
| Super Smash T.V. (World) | |