| Doki Doki Penguin Land - Uchuu Daibouken (Japan) | |
| Double Dragon (World) | |
| Double Hawk (Europe) | |
| Double Hawk (Europe) (Beta) | |
| Double Target - Cynthia no Nemuri (Japan) | |
| Dr. Robotnik's Mean Bean Machine (Europe) | |
| Dragon - The Bruce Lee Story (Europe) | |
| Dragon Crystal (Europe) | |
| Dynamite Duke (Europe) | |
| Dynamite Dux (Europe) | |
| Dynamite Headdy (Brazil) | |
| E-SWAT - City Under Siege (USA, Europe) (Easy Version) | |
| E-SWAT - City Under Siege (USA, Europe) (Hard Version) | |
| Earthworm Jim (Brazil) | |
| Ecco - T | |
| he Tides of Time (Brazil) | |
| Ecco the Dolphin (Europe) | |
| Enduro Racer (Japan) | |
| Enduro Racer (USA, Europe) | |
| Excellent Dizzy Collection, The (USA, Europe) (En,Fr,De,Es,It) (Proto) | |
| F-16 Fighter (USA, Europe) | |
| F-16 Fighting Falcon (Japan) | |
| F-16 Fighting Falcon (USA) | |
| F1 (Europe) | |
| Family Games (Japan) | |
| Fantastic Dizzy (Europe) (En,Fr,De,Es,It) | |
| Fantasy Zone - The Maze (USA, Europe) | |
| Fantasy Zone (Japan) | |
| Fantasy Zone (World) (v1.1) (Beta) | |
| Fantasy Zone (World) (v1.2) | |
| Fantasy Zone II - Opa-Opa no Namida (Japan) | |
| Fantasy Zone II - The Tears of Opa-Opa (USA, Europe) | |
| Ferias Frustradas do Pica Pau (Brazil) | |
| FIFA International Soccer (Brazil) (En,Es,Pt) | |
| Final Bubble Bobble (Japan) | |
| Fire & Forget II (Europe) | |
| Fire & Ice (Brazil) | |
| Flash, The (Europe) | |
| Flintstones, The (Europe) | |
| Forgotten Worlds (Europe) | |
| Fushigi no Oshiro Pit Pot (Japan) | |
| G-LOC Air Battle (Europe) | |
| Gaegujangi Ggachi (Korea) (Unl) | |
| Gain Ground (Europe) | |
| Galactic Protector (Japan) | |
| Galaxy Force (Europe) | |
| Galaxy Force (USA) | |
| Game Box Serie Esportes Radicais (Brazil) | |
| Gangster Town (USA, Europe) | |
| Gauntlet (Europe) | |
| George Foreman's KO Boxing (Europe) | |