| Selection - Erabareshi Mono (Japan) | |
| Selection I & II (Japan) | |
| Selection II - Ankoku no Fuuin (Japan) | |
| Sengoku Ninja-kun (Japan) | |
| Sensible Soccer - European Champions (Europe) | |
| Serpent (USA) | |
| Shadow Warriors (Europe) | |
| Shanghai (Japan) | |
| Shanghai (USA) | |
| Shanghai Pocket (Japan) | |
| Shantae - Force GBA Enhanced Mode | |
| Shaq Fu (USA) | |
| Shikinjou (Japan) | |
| Shin Keiba Kizoku Pocket Jockey (Japan) | |
| Shin Nihon Pro Wrestling - Toukon Sanjuushi (Japan) | |
| Shin SD Gundam Gaiden - Knight Gundam Monogatari (Japan) | |
| Shinri Game 2, The - Oosaka Hen (Japan) | |
| Shinri Game, The (Japan) | |
| Shinseiki GPX Cyber Formula (Japan) | |
| Shippo de Bun (Japan) | |
| Shippuu! Iron Leaguer (Japan) | |
| Shisenshou - Match-Mania (Japan) | |
| Shougi (Japan) | |
| Shougi Saikyou (Japan) | |
| Shougi Saikyou (Japan) (Rev A) | |
| Shounen Ashibe - Yuuenchi Panic (Japan) | |
| Shuyaku Sentai Irem Fighter (Japan) | |
| Side Pocket (World) | |
| Simpsons, The - Bart & the Beanstalk (USA, Europe) | |
| Simpsons, The - Bart vs. the Juggernauts (USA, Europe) | |
| Skate or Die - Bad 'N Rad (Europe) | |
| Skate or Die - Bad 'N Rad (USA) | |
| Skate or Die - Tour de Thrash (USA) | |
| Skinner & The Superintendent | |
| Small Soldiers (USA, Europe) | |
| Smurfs Nightmare, The (Europe) (En,Fr,De,Es) | |
| Smurfs Travel the World, The (Europe) (En,Fr,De,Es) | |
| Smurfs, The (Europe) (En,Fr,De,Es) | |
| Smurfs, The (USA, Europe) (En,Fr,De) (Rev A) | |
| Sneaky Snakes (USA, Europe) | |
| Snoopy - Magic Show (Japan) | |
| Snoopy - Magic Show (USA, Europe) | |
| Snoopy no Hajimete no Otsukai (Japan) | |
| Snow Bros. Jr. (Europe) | |
| Snow Bros. Jr. (Japan) | |
| Snow Bros. Jr. (USA) | |
| Soccer (Europe) (En,Fr,De) | |
| Soccer (Japan) | |
| Soccer Boy (Japan) | |
| Soccer Mania (Japan, USA) | |