| Sa-Ga 2 - Hihou Densetsu (Japan) | |
| Sa-Ga 2 - Hihou Densetsu (Japan) (Rev A) | |
| Sa-Ga 3 - Jikuu no Hasha (Japan) | |
| Sagaia (Japan) | |
| Saigo no Nindou (Japan) | |
| Saint Paradise - Saikyou no Senshi-tachi (Japan) | |
| Sakigake!! Otoko Juku - Meioutou Kessen (Japan) | |
| Same Game (Japan) | |
| Samurai Shodown (USA, Europe) | |
| Sangokushi - Game Boy Ban (Japan) | |
| Sanrio Carnival (Japan) | |
| Sanrio Carnival (Japan) [En by Six Feet Under v1.2] | |
| Sanrio Carnival 2 (Japan) | |
| Sanrio Uranai Party (Japan) | |
| Schiffe Versenken (Germany) (En,Fr,De,Es) | |
| Scotland Yard (Japan) | |
| SD Command Gundam - G-Arms (Japan) | |
| SD Gundam Gaiden - Lacroan' Heroes (Japan) | |
| SD Hiryuu no Ken Gaiden (Japan) | |
| SD Hiryuu no Ken Gaiden 2 (Japan) | |
| SD Lupin III - Kinko Yaburi Daisakusen (Japan) | |
| SD Sengokuden - Kunitori Monogatari (Japan) | |
| SD Sengokuden 2 - Tenka Touitsu Hen (Japan) | |
| SD Sengokuden 3 - Chijou Saikyou Hen (Japan) | |
| Sea Battle (Europe) (En,Fr,De,Es) | |
| SeaQuest DSV (USA, Europe) | |
| Seaside Volley (Japan) | |
| Seiken Densetsu (Japan) | |
| Selection - Erabareshi Mono (Japan) | |
| Selection I & II (Japan) | |
| Selection II - Ankoku no Fuuin (Japan) | |
| Sengoku Ninja-kun (Japan) | |
| Sensible Soccer - European Champions (Europe) | |
| Serpent (USA) | |
| Shadow Warriors (Europe) | |
| Shanghai (Japan) | |
| Shanghai (USA) | |
| Shanghai Pocket (Japan) | |
| Shantae - Force GBA Enhanced Mode | |
| Shaq Fu (USA) | |
| Shikinjou (Japan) | |
| Shin Keiba Kizoku Pocket Jockey (Japan) | |
| Shin Nihon Pro Wrestling - Toukon Sanjuushi (Japan) | |
| Shin SD Gundam Gaiden - Knight Gundam Monogatari (Japan) | |
| Shinri Game 2, The - Oosaka Hen (Japan) | |
| Shinri Game, The (Japan) | |
| Shinseiki GPX Cyber Formula (Japan) | |
| Shippo de Bun (Japan) | |
| Shippuu! Iron Leaguer (Japan) | |
| Shisenshou - Match-Mania (Japan) | |