| Scrabble Blast! (U)(TrashMan) | |
| Scrabble Scramble (E)(Rising Sun) | |
| Scrabble Scramble (E)(Sir VG) | |
| Screw Breaker - Goushin Dorirurero (J)(WRG) | |
| Scurge Hive (E)(Rising Sun) | |
| Scurge Hive (U)(Rising Sun) | |
| SD Gundam Force (J)(Independent) | |
| SD Gundam Force (U)(Rising Sun) | |
| SD Gundam G Generation Advance (J)(Independent) | |
| Sea Trader - Rise of Taipan (U)(Eurasia) | |
| Sea World - Shamu's Deep Sea Adventure (U)(Trashman) | |
| Sega Arcade Gallery (E)(Patience) | |
| Sega Arcade Gallery (U)(TrashMan) | |
| Sega Rally Championship (E)(Patience) | |
| Sega Rally Championship (J)(Eurasia) | |
| Sega Rally Championship (U)(Venom) | |
| Sega Smash Pack (E)(Patience) | |
| Sega Smash Pack (U)(Venom) | |
| Sengoku Kakumei Gaiden (J)(Mugs) | |
| Sennen Kazoku (J)(Supplex) | |
| Sentouin - Yamada Hajime (J)(Rising Sun) | |
| Serious Sam Advance (E)(GBA) | |
| Serious Sam Advance (U)(Rising Sun) | |
| Shaman King - Legacy of the Spirits - Soaring Hawk (U)(Venom) | |
| Shaman King - Legacy of the Spirits - Sprinting Wolf (U)(RisingCaravan) | |
| Shaman King - Master of Spirits (E)(Supplex) | |
| Shaman King - Master of Spirits (U)(Venom) | |
| Shaman King - Master of Spirits 2 (E)(Rising Sun) | |
| Shaman King 2 (J)(Cezar) | |
| Shaman King Chou Senjiryokketsu 3 (J)(Eurasia) | |
| Shamu's Deep Sea Adventures (E)(Sir VG) | |
| Shanghai (J)(Rising Sun) | |
| Shanghai Advance (J)(Independent) | |
| Shark Story (I)(Independent) | |
| Shark Tale (E)(Rising Sun) | |
| Shark Tale (J)(Supplex) | |
| Shark Tale (U)(Hyperion) | |
| Shaun Palmer's Pro Snowboarder (G)(Lightforce) | |
| Shaun Palmer's Pro Snowboarder (U)(Menace) | |
| Sheep (E)(Mode7) | |
| Shifting Gears - Road Trip (U)(Rising Sun) | |
| Shikakui Atama wo Marukusuru Advance - Kanji Keisan (J)(Independent) | |
| Shikakui Atama wo Marukusuru Advance - Kokugo Sansu Rika Shakai (J)(Independent) | |
| Shimura Ken no Bakatonosama (J)(Polla) | |
| Shin Bokura no Taiyou - Gyakushuu no Sabata (J)(Supplex) | |
| Shin Kisekae Monogatari (J)(Rising Sun) | |
| Shin Megami Tensei - Devil Children - Hikari no Sho (J)(Cezar) | |
| Shin Megami Tensei - Devil Children - Puzzle de Call (J)(BatMan) | |
| Shin Megami Tensei - Devil Children - Yami no Sho (J)(Cezar) | |
| Shin Megami Tensei - Devil Children 2 - Honoo no Sho (J)(Rising Sun) | |