| Secret of Mana (USA) [En by FuSoYa v1.0] (Variable Width Font Edition) | |
| Secret of Mana (USA) [En by FuSoYa v1.0] [Hack by Masterflow v1.02] (Hard Mode) | |
| Secret of Mana (USA) [Hack by Masterflow v1.02] (Hard Mode) | |
| Seifuku Densetsu Pretty Fighter (Japan) | |
| Seijuu Maden Beasts & Blades (Japan) | |
| Seiken Densetsu 2 (Japan) | |
| Seiken Densetsu 3 (Japan) | |
| Seiken Densetsu 3 (Japan) (Sample) | |
| Seiken Densetsu 3 (Japan) [En by LNF+Neill Corlett+SoM2Freak v1.01] | |
| Seiken Densetsu 3 (Japan) [En by LNF+Neill Corlett+SoM2Freak v1.01] [Hack by Parlance v1.0] (3 Player Edition) | |
| Seiken Densetsu 3 (Japan) [En by LNF+Neill Corlett+SoM2Freak v1.01] [Title Hack by Dragonsbrethren v1.0] (~Secret of Mana 2) | |
| Sengoku Denshou (Japan) | |
| Sengoku no Hasha - Tenkafubu e no Michi (Japan) | |
| Sensible Soccer - International Edition (Europe) (En,Fr,De,It) | |
| Sensible Soccer (Europe) (En,Fr,De,It) | |
| Sensible Soccer (Europe) (En,Fr,De,It) (Beta) | |
| Septentrion (Japan) | |
| Serizawa Nobuo no Birdie Try (Japan) | |
| Sgt. Saunders' Combat! (Japan) | |
| Shadow, The (USA) (Proto) [50A3] | |
| Shadow, The (USA) (Proto) [97E7] | |
| Shadowrun (Europe) | |
| Shadowrun (Germany) | |
| Shadowrun (Japan) | |
| Shadowrun (Sweden) | |
| Shadowrun (USA) | |
| Shadowrun (USA) (Beta) | |
| Shanghai - Banri no Choujou (Japan) | |
| Shanghai - Banri no Choujou (Japan) (Rev A) | |
| Shanghai II - Dragon's Eye (Europe) | |
| Shanghai II - Dragon's Eye (USA) | |
| Shanghai III (Japan) | |
| Shaq Fu (Europe) | |
| Shaq Fu (USA) | |
| Shaq Fu (USA) (Beta) | |
| Shichuusuimeigaku Nyuumon - Shin Tougenkyou (Japan) | |
| Shien - The Blade Chaser (Japan) | |
| Shien's Revenge (USA) | |
| Shien's Revenge (USA) (Beta) | |
| Shijou Saikyou League Serie A - Ace Striker (Japan) | |
| Shijou Saikyou no Quiz Ou Ketteisen Super (Japan) | |
| Shiki Eiyuuden - Jinryuu Densetsu (Japan) | |
| Shimono Masaki no Fishing to Bassing (Japan) | |
| Shin Chou Kouki (Japan) | |
| Shin Ikkakusenkin (Japan) | |
| Shin Kidou Senki Gundam W - Endless Duel (Japan) | |
| Shin Kidou Senki Gundam W - Endless Duel (Japan) [En by Aeon Genesis v1.0] (~Mobile Suit Gundam Wing - Endless Duel) | |
| Shin Mahjong (Japan) | |
| Shin Megami Tensei (Japan) | |
| Shin Megami Tensei (Japan) (Rev A) | |