| Shougi (Japan) | |
| Shougi Saikyou (Japan) | |
| Shougi Saikyou (Japan) (Rev A) | |
| Shounen Ashibe - Yuuenchi Panic (Japan) | |
| Shuyaku Sentai Irem Fighter (Japan) | |
| Side Pocket (World) | |
| Simpsons, The - Bart & the Beanstalk (USA, Europe) | |
| Simpsons, The - Bart vs. the Juggernauts (USA, Europe) | |
| Skate or Die - Bad 'N Rad (Europe) | |
| Skate or Die - Bad 'N Rad (USA) | |
| Skate or Die - Tour de Thrash (USA) | |
| Skinner & The Superintendent | |
| Small Soldiers (USA, Europe) | |
| Smurfs Nightmare, The (Europe) (En,Fr,De,Es) | |
| Smurfs Travel the World, The (Europe) (En,Fr,De,Es) | |
| Smurfs, The (Europe) (En,Fr,De,Es) | |
| Smurfs, The (USA, Europe) (En,Fr,De) (Rev A) | |
| Sneaky Snakes (USA, Europe) | |
| Snoopy - Magic Show (Japan) | |
| Snoopy - Magic Show (USA, Europe) | |
| Snoopy no Hajimete no Otsukai (Japan) | |
| Snow Bros. Jr. (Europe) | |
| Snow Bros. Jr. (Japan) | |
| Snow Bros. Jr. (USA) | |
| Soccer (Europe) (En,Fr,De) | |
| Soccer (Japan) | |
| Soccer Boy (Japan) | |
| Soccer Mania (Japan, USA) | |
| Solar Striker (World) | |
| Soldam (Japan) | |
| Solitaire (Japan) | |
| Solitaire Funpak (USA, Europe) | |
| Solomon's Club (Europe) | |
| Solomon's Club (Japan) | |
| Solomon's Club (USA) | |
| Sonic 3D Blast 5 (Unl) | |
| Sonic 6 (Unl) | |
| Soreike! Amida-kun (Japan) | |
| Soreyuke! Speedy Gonzales (Japan) | |
| Soreyuke!! Kid (Japan) | |
| Soukoban (Japan) | |
| Soukoban 2 (Japan) | |
| Space Invaders (Europe) | |
| Space Invaders (Japan) | |
| Space Invaders (USA) | |
| Spanky's Quest (Europe) | |
| Start | |
| Game | |
| Spanky's Quest (USA) | |
| Spartan X (Japan) | |
| Speedball 2 - Brutal Deluxe (USA, Europe) | |
| Speedy Gonzales (USA, Europe) | |