| Spider-Man and the X-Men in Arcade's Revenge (USA, Europe) | |
| Spirit of F-1, The (Europe) | |
| Spiritual Warfare (USA) (Unl) | |
| Spirou (Europe) (En,Fr,De,Es) | |
| Spirou (Europe) (En,Fr,De,Es) (Beta) | |
| Splitz - Nigaoe 15 Game (Japan) | |
| Splitz (Europe) | |
| Sports Collection (Japan) | |
| Sports Illustrated - Football & Baseball (USA) | |
| Sports Illustrated - Golf Classic (USA) | |
| Sports Illustrated for Kids - The Ultimate Triple Dare! (USA) | |
| Spot - The Cool Adventure (Japan) | |
| Spot - The Cool Adventure (USA) | |
| Spot (Europe) | |
| Spot (Japan) | |
| Spot (USA) | |
| Spud's Adventure (USA) | |
| Spy vs Spy - Operation Boobytrap (Europe) | |
| Spy vs Spy - Operation Boobytrap (USA) | |
| Square Deal (USA) | |
| Star Hawk (Europe) | |
| Star Sweep (Japan) | |
| Star Trek - 25th Anniversary (USA, Europe) | |
| Star Trek - The Next Generation (Germany) | |
| Star Trek - The Next Generation (Spain) | |
| Star Trek - The Next Generation (USA, Europe) | |
| Star Trek Generations - Beyond the Nexus (Europe) | |
| Star Trek Generations - Beyond the Nexus (USA) | |
| Star Wars - The Empire Strikes Back (Europe) | |
| Star Wars - The Empire Strikes Back (USA) | |
| Star Wars (Europe) | |
| Star Wars (USA, Europe) (Rev A) | |
| Star Wars (USA) | |
| Stargate (USA, Europe) | |
| Stop That Roach! (USA) | |
| Street Fighter II (Japan) | |
| Street Fighter II (USA, Europe) (Rev A) | |
| Street Racer (Japan) | |
| Street Racer (USA, Europe) | |
| Sumo Fighter (USA) | |
| Sumou Fighter - Toukaidou Basho (Japan) | |
| Sunsoft Grand Prix (Europe) | |
| Super B-Daman - Fighting Phoenix (Japan) | |
| Super Battletank - War in the Gulf (USA) | |
| Super Battletank (Europe) | |
| Super Bikkuriman - Densetsu no Sekiban (Japan) | |
| Super Bikkuriman - Densetsu no Sekiban (Japan) [En by PentarouZero v1.0] (~Super Bikkuriman - The Legendary Tablet) | |
| Super Black Bass (USA) | |
| Super Black Bass Pocket (Japan) | |
| Super Black Bass Pocket 2 (Japan) | |