| Shane Warne Cricket (Europe) | |
| Shanghai II - Dragon's Eye (USA) | |
| Shanghai II - Dragon's Eye (USA) (Beta) | |
| Shaq Fu (USA, Europe) | |
| SHC Anthology - prototype builds | |
| SHC2017 expo2017 31 S3K Mania Special Stages By MainMemory | |
| SHC2020 The Real Sonic 2 | |
| SHC2022 Sonic eggman's conquest | |
| Shijie Zhiye Bangqiu Zhengba Sail 94 (China) (Unl) | |
| Shijou Saidai no Soukoban (Japan) | |
| Shikinjoh (Japan) | |
| Shin Souseiki Ragnacenty (Japan) | |
| Shining and the Darkness (Japan) | |
| Shining Force - Kamigami no Isan (Japan) | |
| Shining Force (USA) | |
| Shining Force (USA) (Beta) | |
| Shining Force II - Cheaters Edition | |
| Shining Force II - Koe no Fuuin (Japan) | |
| Shining Force II (Europe) | |
| Shining Force II (USA) | |
| Shining Force II (USA) [Hack by Obob v1.01] (Challenge Mode) | |
| Shining in the Darkness (Brazil) | |
| Shining in the Darkness (USA, Europe) | |
| Shinobi III - Return of the Ninja Master (Europe) | |
| Shinobi III - Return of the Ninja Master (USA) | |
| Shiten Myouou (Japan) | |
| Shougi no Hoshi (Japan) | |
| Shove It! ...The Warehouse Game (USA) | |
| Show do Milhao (Brazil) | |
| Show do Milhao Volume 2 (Brazil) | |
| Show do Milhao Volume 2 (Brazil) (Alt) | |
| Shura no Mon (Japan) | |
| Side Pocket (Europe) | |
| Side Pocket (Japan) | |
| Side Pocket (USA) | |
| Sidney The hedgehog v4 beta 0.3 | |
| Silver in Sonic 2 | |
| Silver Sonic in Sonic 1 | |
| Simpsons, The - Bart Vs The Space Mutants (USA, Europe) | |
| Simpsons, The - Bart Vs The Space Mutants (USA, Europe) (Rev A) | |
| Simpsons, The - Bart's Nightmare (USA, Europe) | |
| Skeleton Krew (Europe) | |
| Skeleton Krew (USA) | |
| Skitchin (USA, Europe) | |
| Slap Fight MD (Japan) | |
| Slaughter Sport (USA) | |
| Slime World (Japan) | |
| SMB1 Mario in Sonic The Hedgehog | |
| Smurfs Travel the World, The (Europe) (En,Fr,De,Es) | |
| Smurfs, The (Europe) (En,Fr,De,Es,It) | |