| Unou Kaiten - Match Bou Puzzle DS (Japan) | |
| Unou no Tatsujin - GunBulleTrainer (Japan) | |
| Unou no Tatsujin - Hirameki Kosodate My Angel (Japan) | |
| Unou no Tatsujin - Soukai! Machigai Museum (Japan) | |
| Unou no Tatsujin - Soukai! Machigai Museum 2 (Japan) | |
| Unou Nouryoku Check Machine - Touch de Unoo! DS (Japan) | |
| Unou Tanren Unotan DS - Shichida Shiki Otona no Shun Kan Training (Japan) | |
| Unou Tanren Unotan DS - Shichida Shiki Otona no Sokudoku Training (Japan) | |
| Unsolved Crimes (Europe) (En,Fr,De,Es,It) | |
| Unsolved Crimes (USA) | |
| Up (Europe) | |
| Up (Europe) (Fr,De,Nl) | |
| Up (Europe) (Sv,No,Da) | |
| Up (Italy) | |
| Up (Korea) | |
| Up (Spain) | |
| Up (USA) (En,Fr) | |
| Uranai Demo Shite Miyouka DS (Japan) | |
| Urbz, The - Sims in the City (Europe) (En,Fr,De,Es,It) | |
| Urbz, The - Sims in the City (Japan) | |
| Urbz, The - Sims in the City (USA) | |
| Urusei Yatsura - Endless Summer (Japan) | |
| USA Today Crossword Challenge (USA) (En,Es) | |
| USA Today Puzzle Craze (USA) | |
| Utacchi (Japan) | |
| Utsukushii Nihongo no Kakikata Hanashikata DS (Japan) | |
| Utsukushiku Narou - Duke Saraie no Kenkou Walking Navi (Japan) | |
| Uwasa no Midori-kun!! - Natsuiro Striker (Japan) | |
| Uwasa no Midori-kun!! 2 - Futari no Midori! (Japan) | |
| V8 Supercars Australia 3 - Create & Race (Australia) (En,Fr,De,Es,It) | |
| Valentines Day (Europe) | |
| Valkyrie Profile - Covenant of the Plume (Europe) | |
| Valkyrie Profile - Covenant of the Plume (USA) | |
| Valkyrie Profile - Toga o Seou Mono (Japan) | |
| Vampire Knight DS (Japan) | |
| Vampire Legends - Power of Three (USA) (NDSi Enhanced) | |
| Vampire Moon - The Mystery of the Hidden Sun (Europe) (En,Fr,De,Es,It,Nl) | |
| Vampire Moon - The Mystery of the Hidden Sun (USA) (En,Fr,Es) | |
| Vecinos Invasores (Spain) | |
| Vegas Casino (USA) | |
| Vegas Casino High 5! (Europe) (En,Fr,De,Es,It) | |
| Veronica Poker (Netherlands) | |
| Victorious - Hollywood Arts Debut (Europe) (En,Fr,De,Es,It) | |
| Victorious - Hollywood Arts Debut (USA) (En,Fr,De,Es,It) | |
| Victorious - Taking the Lead (Europe) (En,Fr,De,Es,It) | |
| Victorious - Taking the Lead (USA) (En,Fr,De,Es,It) | |
| Vie d'Emma, La - Infirmiere de Choc (France) | |
| Vie d'Emma, La - Super Star (Europe) (En,Fr,It) | |
| Viewtiful Joe - Double Trouble! (Europe) | |
| Viewtiful Joe - Double Trouble! (France) | |