| Retro Game Challenge (USA) | |
| Reversal Challenge (USA) | |
| Revo Kart DS Demo 2.1 | |
| Rhapsody - A Musical Adventure (Europe) (En,Fr) | |
| Rhapsody - A Musical Adventure (USA) | |
| Rhythm 'n Notes - Improve Your Music Skills (USA) | |
| Rhythm 'n Notes (Europe) (En,Fr,Es,It) | |
| Rhythm de Cooking - Sweets Party e Youkoso (Japan) | |
| Rhythm de Run Run Run (Japan) | |
| Rhythm Heaven (USA) | |
| Rhythm Paradise (Europe) (En,Es,It) | |
| Rhythm Paradise (Europe) (En,Fr,De) | |
| Rhythm Sesang (Korea) | |
| Rhythm Tengoku Gold (Japan) | |
| Ridge Racer DS (USA, Europe) | |
| Riding Star 3 (Europe) (En,Fr,De,Es,It) | |
| Rijexamen Training 2008 - Code de la Route 2008 (Europe) (Fr,Nl) | |
| Rilakkuma Rhythm - Mattari Kibun de Dararan Ran (Japan) | |
| Ringling Bros. and Barnum & Bailey - Circus Friends - Asian Elephants (USA) | |
| Ringling Bros. and Barnum & Bailey - It's My Circus - Elephant Friend (Europe) (En,Fr,De,Es,It) | |
| Rise of the Guardians (USA) (En,Fr,Es) | |
| Rittai Picross (Japan) | |
| River City - Soccer Hooligans (USA) | |
| River City - Super Sports Challenge (USA) | |
| River King - Mystic Valley (USA) | |
| Riz-Zoawd (Japan) | |
| Road to Vegas (Europe) | |
| Roary the Racing Car (Europe) | |
| Robbie Konijn - Leer Lezen en Schrijven (Netherlands) | |
| Robocalypse (USA) | |
| Robots (Europe) (En,Fr,De,Es,It) | |
| Robots (Japan) | |
| Robots (USA) | |
| Rock Band 3 (Europe) (En,Fr,De,Es,It) | |
| Rock Band 3 (USA) (En,Fr,De,Es,It) | |
| Rock Blast (USA) | |
| Rock Revolution (Europe) (En,Fr,De,Es,It,Sv,No,Da,Fi) | |
| Rock Revolution (USA) (En,Fr,Es) | |
| Rockin' Pretty (USA) | |
| Rockman EXE - Operate Shooting Star (English) | |
| Rockman EXE - Operate Shooting Star (Japan) | |
| Rockman EXE 5 DS - Twin Leaders (Japan) | |
| Rockman Zero Collection (Japan) | |
| Rockman ZX - Advent (Japan) | |
| Rockman ZX (Japan) | |
| Rollercoaster Park (Europe) (En,Fr,Nl) | |
| Rollin' Rascals (USA) | |
| Rondo of Swords (USA) | |
| Roogoo Attack! (USA) (En,Fr,De,Es,It) | |
| Rooms - Fushigi na Ugoku Heya (Japan) | |