| Simple DS Series Vol. 40 - The Gekai (Japan) | |
| Simple DS Series Vol. 41 - The Bakudan Shorihan (Japan) | |
| Simple DS Series Vol. 42 - The Haioku Byoutou - Norowareta Byouin kara no Dasshutsu (Japan) | |
| Simple DS Series Vol. 43 - The Host Shiyouze! - DX Night King (Japan) | |
| Simple DS Series Vol. 44 - The Gal Mahjong (Japan) | |
| Simple DS Series Vol. 45 - The Misshitsu kara no Dasshutsu 2 (Japan) | |
| Simple DS Series Vol. 46 - The Hikyou Tankentai - Choujou Special 'Kyoui! Jinrui Mitou no Sekai Kakuchi ni Nazo no Mikakunin Seibutsu wa Sonzai Shita!!' (Japan) | |
| Simple DS Series Vol. 47 - The Suiri - Shinshou 2009 (Japan) | |
| Simple DS Series Vol. 48 - The Saibanin - 1-tsu no Shinjitsu, 6-tsu no Kotae (Japan) | |
| Simple DS Series Vol. 5 - T | |
| he Trump (Japan) | |
| Simple DS Series Vol. 6 - The Party Game (Japan) | |
| Simple DS Series Vol. 7 - The Illust Puzzle & Suuji Puzzle (Japan) | |
| Simple DS Series Vol. 7 - The Illust Puzzle & Suuji Puzzle (Japan) (Rev 1) | |
| Simple DS Series Vol. 8 - The Kanshikikan - Kinkyuu Shutsudou! Jiken Genba o Touch Seyo! (Japan) | |
| Simple DS Series Vol. 9 - Atama ga Yokunaru - The Me no Training (Japan) | |
| Simpson, I - Il Videogioco (Italy) | |
| Simpson, Les - Le Jeu (France) | |
| Simpson, Los - El Videojuego (Spain) | |
| Simpsons Game, The (Europe) | |
| Simpsons Game, The (USA) | |
| Simpsons, Die - Das Spiel (Germany) | |
| Sims 2, The - Apartment Pets (Europe) (En,Fr,De,Es,It,Nl) | |
| Sims 2, The - Apartment Pets (USA) (En,Fr,De,Es,It,Nl) | |
| Sims 2, The - Castaway (Europe) (En,Fr,De,Es,It,Nl,Pt) | |
| Sims 2, The - Castaway (Korea) | |
| Sims 2, The - Castaway (USA) (En,Fr,De,Es,It,Nl,Pt) | |
| Sims 2, The - Hachamecha Hotel Life (Japan) | |
| Sims 2, The - Pet Wannyan Life (Japan) | |
| Sims 2, The - Pets (Europe) (En,Fr,De,Es,It,Nl) | |
| Sims 2, The - Pets (USA) (En,Fr,De,Es,It,Nl) | |
| Sims 2, The - Survival (Japan) | |
| Sims 2, The (Europe) (En,Fr,De,Es,It) | |
| Sims 2, The (USA) (En,Fr,De,Es,It) | |
| Sims 3, The (Europe) (En,Fr,De,Es,It,Nl) (NDSi Enhanced) | |
| Six Flags Fun Park (USA) (En,Fr) | |
| Skate It (Europe) (En,Fr,De,Es,It,Nl) | |
| Skate It (USA) (En,Fr,De,Es,It,Nl) | |
| Slide Adventure - Mag Kid (Japan) | |
| Slime Morimori Dragon Quest 2 - Daisensha to Shippo Dan (Japan) | |
| Slingo Quest (USA) | |
| Sloane to MacHale no Nazo no Story (Japan) | |
| Sloane to MacHale no Nazo no Story 2 (Japan) | |
| Smart Boy's Gameroom (USA) | |
| Smart Boy's Gameroom 2 (USA) | |
| Smart Boy's Toys Club (USA) | |
| Smart Boy's Winter Wonderland (USA) | |
| Smart Girl's Magical Book Club (USA) | |
| Smart Girl's Party Game (USA) | |
| Smart Girl's Playhouse (USA) | |
| Smart Girl's Playhouse 2 (USA) | |